Applicable Versions: 5.00.0050 onwards
The ServerSecurity settings, data is stored in a file on disk in the ProgramData folder on the server.
We have an example program that stops the DataPA Enterprise Service, opens this file from disk, makes some changes before restarting the service.
The example program ConfigureEnterprise.p is available here.
Information regarding the settings that can be changed is available in the Developer API.